Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.43 |
| ▸ | ITK | Q08881 | 6/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317600 | 0.81 | LMNA (0.47) | LMNAL3MBTL1HRH3MRGPRX2ITK | |
| SCHEMBL5319144 | 0.81 | LMNA (0.60) | LMNAL3MBTL1HRH3MRGPRX2ITK | |
| SCHEMBL5321947 | 0.74 | HRH3 (0.50) | LMNAL3MBTL1HRH3MRGPRX2ITK | |
| SCHEMBL5315402 | 0.73 | CNR2 (0.48) | MRGPRX2ITKADORA2AADORA1CNR2 | |
| SCHEMBL5317461 | 0.71 | HDAC6 (0.62) | LMNAMRGPRX2ITKADORA2AADORA1 | |
| SCHEMBL5320022 | 0.71 | ADORA2A (0.49) | HRH3MRGPRX2ITKADORA2AADORA1 | |
| SCHEMBL5316556 | 0.71 | HDAC6 (0.63) | LMNAL3MBTL1HRH3MRGPRX2ITK | |
| SCHEMBL5317398 | 0.70 | ITK (0.49) | MRGPRX2ITKCNR2NPC1RAB9A | |
| SCHEMBL10817171 | 0.69 | MAPT (0.51) | LMNACNR2RAB9A | |
| SCHEMBL5320783 | 0.69 | ITK (0.47) | MRGPRX2ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |