Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 4/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ERG | P11308 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316212 | 0.88 | KCNH2 (0.46) | KCNH2ALDH1A1GAASMN1; SMN2CD274 | |
| SCHEMBL2967576 | 0.87 | KCNH2 (0.47) | KCNH2USP14DRD2DRD3 | |
| SCHEMBL5314436 | 0.84 | KCNH2 (0.46) | KCNH2ALDH1A1GAASMN1; SMN2USP14 | |
| SCHEMBL5316942 | 0.84 | LTA4H (0.46) | KCNH2ALDH1A1GAASMN1; SMN2HTR1A | |
| SCHEMBL5314550 | 0.84 | CD274 (0.53) | KCNH2CD274DRD2DRD3 | |
| SCHEMBL2966340 | 0.84 | SIGMAR1 (0.40) | KCNH2DRD2HTR1ADRD3 | |
| SCHEMBL5320727 | 0.80 | SCN8A (0.45) | KCNH2ALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL2966852 | 0.79 | KCNH2 (0.44) | KCNH2KMT2ADRD2DRD3 | |
| SCHEMBL4125747 | 0.78 | KCNH2 (0.48) | KCNH2CD274GPBAR1DRD2DRD3 | |
| SCHEMBL3423966 | 0.77 | SIGMAR1 (0.45) | KCNH2DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |