Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316212 | 0.85 | KCNH2 (0.46) | KCNH2KMT2ADRD2POLBMAPT | |
| SCHEMBL5316942 | 0.83 | LTA4H (0.46) | KCNH2HTR1AABCB1HPGDABCG2 | |
| SCHEMBL5314436 | 0.81 | KCNH2 (0.46) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5316722 | 0.80 | KCNH2 (0.43) | KCNH2KMT2AHTR1ADRD2POLB | |
| SCHEMBL4669235 | 0.78 | KCNH2 (0.44) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL4134193 | 0.77 | KCNH2 (0.53) | KCNH2MEN1KCNA5ALDH1A1 | |
| SCHEMBL4125747 | 0.77 | KCNH2 (0.48) | KCNH2DRD2 | |
| SCHEMBL4668152 | 0.75 | KCNH2 (0.44) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5315943 | 0.74 | KCNH2 (0.51) | KCNH2KMT2AMEN1HTR1ADRD2 | |
| SCHEMBL2967590 | 0.74 | KCNH2 (0.44) | KCNH2HTR1ADRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |