Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.41 |
| ▸ | PIK3R3 | Q92569 | 2/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31429395 | 0.90 | CYP3A4 (0.44) | SSTR4CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2078485 | 0.87 | HTR3A (0.46) | CYP3A4CYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL3411552 | 0.87 | KDM4E (0.47) | — | |
| SCHEMBL8718634 | 0.86 | KDM4E (0.49) | — | |
| SCHEMBL31195556 | 0.80 | SSTR4 (0.45) | SSTR4HTR4CREBBPKDM4CHSD11B1 | |
| SCHEMBL25233771 | 0.78 | MEN1 (0.40) | CYP3A4CYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL15882181 | 0.77 | HTR4 (0.48) | HTR4CYP3A4PIK3CDPIK3R2PIK3CA | |
| SCHEMBL31429308 | 0.77 | HTR4 (0.48) | HTR4CYP3A4PIK3CDPIK3R2PIK3CA | |
| SCHEMBL31429241 | 0.76 | HTR4 (0.52) | HTR4CYP3A4 | |
| SCHEMBL15882124 | 0.76 | ROCK1 (0.53) | HTR4CYP3A4CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828179-A2 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | Memory Pharmaceutical Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1745046-A2 | 1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZIOSOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2006069097-A2 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |
| WO-2005111038-A2 | 1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |