Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.57 |
| ▸ | ITK | Q08881 | 6/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | PLCG1 | P19174 | 7/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312257 | 0.90 | CHRNA7 (0.61) | BTKITKCHRNA7PLCG1IRAK1 | |
| SCHEMBL14494777 | 0.88 | CHRNA7 (0.55) | BTKITKCHRNA7PLCG1 | |
| SCHEMBL14495029 | 0.84 | CHRNA7 (0.52) | BTKITKCHRNA7PLCG1JAK3 | |
| SCHEMBL5315796 | 0.83 | CHRNA7 (0.51) | BTKITKCHRNA7PLCG1EPHB4 | |
| SCHEMBL14494779 | 0.81 | CHRNA7 (0.53) | CHRNA7EPHB4 | |
| SCHEMBL5314889 | 0.80 | CHRNA7 (0.57) | CHRNA7EPHB4PDGFRAKDR | |
| SCHEMBL5315210 | 0.79 | CHRNA7 (0.61) | BTKCHRNA7 | |
| SCHEMBL14495087 | 0.79 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL14494780 | 0.77 | CHRNA7 (0.59) | CHRNA7EPHB4 | |
| SCHEMBL5372937 | 0.77 | CHRNA7 (0.58) | BTKCHRNA7EPHB4PDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062459-A1 | SELECTIVE KINASE INHIBITORS BASED ON PYRIDINE SCAFFOLD | CYTOPIA RESEARCH PTY LTD (AU) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007062459-A1 | SELECTIVE KINASE INHIBITORS BASED ON PYRIDINE SCAFFOLD | CYTOPIA RESEARCH PTY LTD (AU) | 2007-06-07 | — | — | WO | disclosed |