Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.67 |
| ▸ | VNN1 | O95497 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266738 | 0.83 | LTA4H (0.53) | LTA4HVNN1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL18228575 | 0.82 | LTA4H (0.66) | LTA4HALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL30642394 | 0.80 | LTA4H (1.00) | LTA4HVNN1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL523753 | 0.80 | LTA4H (1.00) | LTA4HVNN1ALDH1A1MEN1CYP1A2 | |
| SCHEMBL5268459 | 0.78 | HIF1A (0.46) | LTA4HVNN1MEN1CYP3A4KMT2A | |
| SCHEMBL4147302 | 0.78 | VNN1 (0.52) | LTA4HVNN1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5265213 | 0.77 | HDAC1 (0.46) | LTA4HVNN1MEN1CYP1A2CYP3A4 | |
| SCHEMBL2065031 | 0.77 | CYP1A2 (0.69) | LTA4HALDH1A1MEN1CYP1A2CYP3A4 | |
| N-Benzylaniline SCHEMBL7840 | 0.77 | HTT (0.71) | LTA4HALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL22628164 | 0.77 | HTT (0.71) | LTA4HALDH1A1MEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288433-A1 | NOVEL COMPOUNDS | Cerevance, Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022167819-A1 | NOVEL COMPOUNDS | Cerevance, Inc. (US) | 2022-08-11 | — | — | WO | disclosed |
| US-20070287716-A1 | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors | MERCK SHARP & DOHME CORP. | 2007-12-13 | — | — | US | disclosed |
| EP-1809608-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006049968-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287716-A1 | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors | GRM2, GRM1, GRIN2A | LTA4H 3270/4885VNN1 4400/4885TAAR1 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.