Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317264 | 0.83 | LTA4H (0.67) | LTA4HVNN1MEN1KMT2AFFAR1 | |
| SCHEMBL5265213 | 0.83 | HDAC1 (0.46) | LTA4HMETAP2VNN1MEN1MAPT | |
| SCHEMBL5269412 | 0.80 | CYP1A2 (0.44) | LTA4HVNN1ALDH1A1USP2CYP1A2 | |
| SCHEMBL5268459 | 0.78 | HIF1A (0.46) | LTA4HVNN1MEN1MAPTPABPC1 | |
| SCHEMBL609110 | 0.75 | CALM1 (0.60) | LTA4HFDPS | |
| SCHEMBL20917287 | 0.74 | CACNA2D1 (0.50) | — | |
| SCHEMBL11719477 | 0.74 | MAOA (0.68) | MEN1MAPTKMT2APTPN11KDM4E | |
| SCHEMBL5267165 | 0.74 | VNN1 (0.58) | VNN1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL6690772 | 0.73 | HTT (0.57) | LTA4HMETAP2MEN1KMT2AF2 | |
| SCHEMBL18228575 | 0.71 | LTA4H (0.66) | LTA4HMEN1MAPTPABPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287716-A1 | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors | MERCK SHARP & DOHME CORP. | 2007-12-13 | — | — | US | disclosed |
| EP-1809608-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006049968-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287716-A1 | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors | GRM2, GRM1, GRIN2A | LTA4H 3270/4885METAP2 643/4885VNN1 4400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.