Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | MC4R | P32245 | 4/20 | 0.41 |
| ▸ | MC3R | P41968 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317667 | 1.00 | SLC6A7 (0.53) | SLC6A7TRPV1RIPK1NAMPTSIGMAR1 | |
| SCHEMBL3433329 | 0.87 | SLC6A7 (0.49) | SLC6A7TRPV1RIPK1NAMPTMC4R | |
| SCHEMBL3433327 | 0.87 | SLC6A7 (0.49) | SLC6A7TRPV1RIPK1NAMPTMC4R | |
| SCHEMBL3434053 | 0.82 | RIPK1 (0.52) | SLC6A7TRPV1RIPK1NAMPTTDP1 | |
| SCHEMBL3430814 | 0.80 | SLC6A7 (0.47) | SLC6A7TRPV1RIPK1NAMPTKDM4E | |
| SCHEMBL3430815 | 0.80 | SLC6A7 (0.47) | SLC6A7TRPV1RIPK1NAMPTKDM4E | |
| SCHEMBL27702525 | 0.79 | SLC6A7 (0.63) | SLC6A7TRPV1RIPK1NAMPTKDM4E | |
| SCHEMBL4813898 | 0.78 | SLC6A7 (0.66) | SLC6A7TRPV1RIPK1NAMPTKDM4E | |
| SCHEMBL936568 | 0.77 | SIGMAR1 (0.42) | SIGMAR1ARTDP1KDM4EHTT | |
| SCHEMBL2011822 | 0.76 | SLC6A7 (0.56) | SLC6A7TRPV1RIPK1NAMPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851205-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086447-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-08-17 | — | — | WO | disclosed |