Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123989 | 0.83 | NSD2 (0.42) | NSD2ALDH1A1MLYCDHPGD | |
| SCHEMBL5317404 | 0.81 | NSD2 (0.58) | NSD2GSK3BCA1CA2KMT2A | |
| SCHEMBL10933810 | 0.80 | NSD2 (0.55) | NSD2GSK3BCA1CA2KMT2A | |
| SCHEMBL13151106 | 0.78 | NSD2 (0.54) | NSD2GSK3BCA1CA2KMT2A | |
| SCHEMBL7533635 | 0.77 | ALDH1A1 (0.55) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL6796753 | 0.76 | NSD2 (0.77) | NSD2CA2KMT2AMEN1NPC1 | |
| SCHEMBL294286 | 0.76 | KMT2A (0.53) | KMT2AMEN1ALDH1A1MAPTMLYCD | |
| SCHEMBL23015300 | 0.75 | NSD2 (1.00) | NSD2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL5414969 | 0.75 | NSD2 (0.52) | NSD2GSK3BCA1CA2KMT2A | |
| SCHEMBL7236313 | 0.75 | NSD2 (0.71) | NSD2KMT2AMEN1NPC1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |