Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.45 |
| ▸ | GNRHR | P30968 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315555 | 0.89 | KDM4E (0.49) | KDM4EPKMUTS2RGNRHRFPR3 | |
| SCHEMBL5318149 | 0.85 | HTR4 (0.41) | KDM4EPKMACHEHTR4LMNA | |
| SCHEMBL5318283 | 0.80 | KDM4E (0.49) | KDM4EPKMUTS2RGNRHRACHE | |
| SCHEMBL17709663 | 0.79 | HTR4 (0.66) | KDM4EPKMACHEHTR4TP53 | |
| SCHEMBL5214369 | 0.78 | HTR4 (0.64) | KDM4EPKMUTS2RHTR4 | |
| SCHEMBL13610955 | 0.77 | KDM4E (0.39) | KDM4EPKMUTS2RHTR4MEN1 | |
| SCHEMBL13603086 | 0.77 | KDM4E (0.39) | KDM4EPKMUTS2RHTR4MEN1 | |
| SCHEMBL17796229 | 0.75 | KDM4E (0.72) | KDM4EPKMUTS2RGNRHRTP53 | |
| SCHEMBL5315558 | 0.75 | HTR4 (0.41) | ACHEHTR4 | |
| SCHEMBL5316909 | 0.74 | HTR4 (0.51) | ACHEHTR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |