Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315558 | 0.89 | HTR4 (0.41) | HTR4ACHETPSAB1TPSD1TPSG1 | |
| SCHEMBL5318148 | 0.85 | KDM4E (0.53) | HTR4ACHEKDM4EPKMLMNA | |
| SCHEMBL5318285 | 0.80 | HTR4 (0.49) | HTR4ACHEADRA2CADRA1AHTR3A | |
| SCHEMBL5316910 | 0.76 | HTR4 (0.51) | HTR4ACHEHTR2CADRA2CHTR1D | |
| SCHEMBL5315555 | 0.75 | KDM4E (0.49) | HTR4ACHEKDM4EPKMLMNA | |
| SCHEMBL5317371 | 0.74 | KCNH2 (0.43) | HTR4TPSAB1TPSD1TPSG1F2 | |
| SCHEMBL5315379 | 0.73 | KCNH2 (0.41) | HTR4TPSAB1TPSD1TPSG1F2 | |
| Hydrochloric Acid SCHEMBL27351702 | 0.72 | KCNH2 (0.57) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL14382457 | 0.71 | HTR4 (0.44) | HTR4ACHEHTR3AHTR3EHTR3B | |
| SCHEMBL7436618 | 0.70 | HTR4 (0.35) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |