Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.61 |
| ▸ | FLT1 | P17948 | 9/20 | 0.61 |
| ▸ | FLT4 | P35916 | 9/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.58 |
| ▸ | VCP | P55072 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316767 | 0.88 | VCP (0.60) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL5316678 | 0.80 | FLT1 (0.60) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL14466071 | 0.78 | FLT1 (0.52) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL24155698 | 0.77 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2 | |
| Gw549390X SCHEMBL3295009 | 0.77 | KDR (1.00) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL14466975 | 0.76 | KDR (0.60) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL5502826 | 0.76 | IMPDH2 (0.68) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL15121057 | 0.76 | KDR (0.47) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL5316815 | 0.74 | KDR (0.57) | KDRFLT1FLT4IMPDH2VCP | |
| SCHEMBL15878912 | 0.74 | KDR (0.79) | KDRFLT1FLT4IMPDH2VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |