Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 3/20 | 0.60 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | FLT1 | P17948 | 6/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318202 | 0.88 | KDR (0.61) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5316678 | 0.81 | FLT1 (0.60) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL14466071 | 0.78 | FLT1 (0.52) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5316742 | 0.77 | SIRT7 (0.60) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL5316983 | 0.77 | VCP (0.58) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL29118415 | 0.76 | NPC1 (0.46) | FLT4SRCPRKAA1 | |
| SCHEMBL5318423 | 0.75 | VCP (0.56) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL14465944 | 0.75 | VCP (1.00) | VCPSIRT7KDRFLT1FLT4 | |
| SCHEMBL14466945 | 0.75 | VCP (0.74) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL5318254 | 0.75 | VCP (0.58) | VCPSIRT7IMPDH2KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |