Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 9/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315558 | 0.90 | HTR4 (0.41) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5318283 | 0.87 | KDM4E (0.49) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5318149 | 0.80 | HTR4 (0.41) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL17978305 | 0.80 | HTR4 (0.54) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL505450 | 0.80 | HTR4 (0.58) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL17978155 | 0.80 | HTR4 (0.49) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL17978242 | 0.79 | HTR4 (0.53) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5317371 | 0.79 | KCNH2 (0.43) | HTR4HTR3AKCNH2 | |
| SCHEMBL17978193 | 0.79 | HTR4 (0.49) | HTR4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL2329533 | 0.79 | HTR4 (0.51) | HTR4HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |