Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102177 | 0.80 | MAPT (0.48) | MAPTATMHPGDKDM4ETDP1 | |
| SCHEMBL1200363 | 0.79 | FKBP1A (0.39) | MAPTCYP3A4LMNAKCNK3 | |
| SCHEMBL3963948 | 0.73 | SMN1; SMN2 (0.36) | LMNAKCNK3 | |
| SCHEMBL2685827 | 0.72 | OPRM1 (0.35) | HPGDKDM4EALDH1A1 | |
| SCHEMBL5317670 | 0.70 | ALDH1A1 (0.36) | KDM4ECYP3A4KMT2AALDH1A1 | |
| SCHEMBL3834072 | 0.69 | KDM4E (0.48) | MAPTATMHPGDL3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL3830058 | 0.68 | TDP1 (0.48) | MAPTATMHPGDL3MBTL1KDM4E | |
| SCHEMBL13102199 | 0.67 | MAPT (0.57) | MAPTATMHPGDL3MBTL1KDM4E | |
| SCHEMBL13995369 | 0.67 | KDM4E (0.44) | MAPTATMHPGDL3MBTL1KDM4E | |
| SCHEMBL23920414 | 0.65 | NR1I2 (0.45) | L3MBTL1CYP3A4LMNAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |