Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477123 | 0.78 | HDAC1 (0.41) | HRH4ATRSMN1; SMN2 | |
| SCHEMBL7958970 | 0.77 | SIGMAR1 (0.42) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL4336868 | 0.77 | GAA (0.60) | HRH4RENMAPK1MEN1KMT2A | |
| SCHEMBL20267367 | 0.76 | SIGMAR1 (0.62) | POLBMEN1KMT2ASIGMAR1 | |
| SCHEMBL1090206 | 0.75 | SIGMAR1 (0.65) | HRH4ATRRENHPGDKMT2A | |
| SCHEMBL1090204 | 0.75 | SIGMAR1 (0.65) | HRH4ATRRENHPGDKMT2A | |
| SCHEMBL10293578 | 0.75 | SIGMAR1 (0.65) | HRH4ATRRENHPGDKMT2A | |
| SCHEMBL13490134 | 0.74 | HTR2C (0.58) | HRH4USP30MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2787453 | 0.74 | HTR2C (0.58) | HRH4USP30MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2579734 | 0.74 | HTR2C (0.58) | HRH4USP30MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844052-A1 | THIENO[2,3-D]PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | Pharmacia & Upjohn Company LLC (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006079916-A1 | THIENO [2,3-D] PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-08-03 | — | — | WO | disclosed |