Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319191 | 0.80 | CCR1 (0.38) | CCR2 | |
| SCHEMBL5315280 | 0.78 | CCR2 (0.64) | CCR2 | |
| SCHEMBL5946991 | 0.74 | CCR2 (0.51) | CCR2 | |
| SCHEMBL5946996 | 0.74 | CCR2 (0.51) | CCR2 | |
| SCHEMBL9653792 | 0.71 | GPR183 (0.60) | CCR2GPR183GAANPC1RAB9A | |
| SCHEMBL9653786 | 0.71 | GPR183 (0.60) | CCR2GPR183GAANPC1RAB9A | |
| SCHEMBL14386912 | 0.71 | CCR2 (0.68) | CCR2GPR183NPC1RAB9A | |
| SCHEMBL5325883 | 0.71 | CCR2 (0.68) | CCR2GPR183NPC1RAB9A | |
| SCHEMBL9654393 | 0.70 | HPGD (0.78) | GPR183GAANPC1RAB9ALMNA | |
| SCHEMBL9654396 | 0.70 | HPGD (0.78) | GPR183GAANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802602-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006036527-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | disclosed |