Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 8/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319196 | 0.80 | CCR2 (0.56) | CCR2 | |
| SCHEMBL5315276 | 0.78 | CCR2 (0.44) | CCR1CCR2DRD2 | |
| SCHEMBL5325878 | 0.70 | CCR1 (0.44) | CCR1CCR2 | |
| SCHEMBL5264815 | 0.70 | CCR2 (0.44) | CCR2USP5 | |
| SCHEMBL5322924 | 0.68 | CCR2 (0.37) | CCR2ADRA2ADRD1DRD5ADRA1B | |
| SCHEMBL5325882 | 0.67 | CCR1 (0.36) | CCR1CCR2ADRA2ADRD1DRD5 | |
| SCHEMBL5333448 | 0.64 | TACR1 (0.36) | CCR2ADRA2ADRD1DRD5ADRA1B | |
| SCHEMBL2159557 | 0.64 | CCR1 (0.81) | CCR1 | |
| SCHEMBL22688514 | 0.63 | P2RY14 (0.57) | ADRA2ADRD1DRD5ADRA1BP2RY14 | |
| SCHEMBL5315280 | 0.62 | CCR2 (0.64) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802602-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006036527-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | disclosed |