Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10873009 | 0.94 | HPGD (0.55) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10871420 | 0.94 | HPGD (0.55) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10870757 | 0.94 | HPGD (0.73) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10872144 | 0.89 | HPGD (0.50) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10871883 | 0.89 | HPGD (0.50) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10874045 | 0.89 | HPGD (0.66) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10870481 | 0.89 | KMT2A (0.66) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL10871424 | 0.88 | LMNA (0.48) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL1021140 | 0.83 | HTT (0.59) | HPGDLMNAALDH1A1MAPK1MAPT | |
| SCHEMBL2553786 | 0.82 | HPGD (0.55) | HPGDLMNAL3MBTL1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148972-B1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS INC (US) | 2019-08-21 | — | — | EP | disclosed |
| US-9682938-B2 | Pyrazolone derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| EP-3148972-A1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183839-A1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2015-12-03 | — | — | WO | disclosed |
| US-20150344437-A1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY | 2015-12-03 | — | — | US | disclosed |
| WO-2007114902-A2 | ALKYLTHIOBENZYLPIPERIDINE COMPOUNDS | H.LUNDBECK A/S (DK) | 2007-10-11 | — | — | WO | disclosed |
| EP-0235345-B1 | INDENE COMPOUNDS | Taiyo Pharmaceutical Industry Co., Ltd. (JP) | 1992-10-14 | — | — | EP | disclosed |
| US-4876345-A | VASODILATORS, CALCIUM ANTAGONISTS; ANGINA PECTORIS | TAIYO PHARMACEUTICAL INDUSTRY CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| US-4762927-A | ANGINA PECTORIS | TAIYO PHARMACEUTICAL INDUSTRY CO., LTD. (JP) | 1988-08-09 | — | — | US | disclosed |
| EP-0235345-A1 | Indene compounds | Taiyo Pharmaceutical Industry Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344437-A1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | TNNI3, PFKP, NOX5 | HPGD 19/4885LMNA 2480/4885L3MBTL1 4438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.