Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.78 |
| ▸ | VCP | P55072 | 3/20 | 0.57 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | FLT4 | P35916 | 6/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319550 | 0.77 | VCP (0.72) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL5319106 | 0.76 | SIRT7 (0.64) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL29620974 | 0.75 | VCP (0.51) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL24636886 | 0.74 | VCP (0.53) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL29621095 | 0.74 | VCP (0.53) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL5316742 | 0.73 | SIRT7 (0.60) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL14466945 | 0.72 | VCP (0.74) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL14465944 | 0.72 | VCP (1.00) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL29620933 | 0.71 | VCP (0.50) | KDRVCPSIRT7FLT1FLT4 | |
| SCHEMBL21258999 | 0.71 | NPC1 (0.60) | KDRKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |