Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315252 | 0.89 | BAZ2B (0.48) | PTGDR2AKR1B10AKR1B1BAZ2BSMN1; SMN2 | |
| SCHEMBL5316996 | 0.83 | TP53 (0.53) | PTGDR2AKR1B10AKR1B1BAZ2BTP53 | |
| SCHEMBL29034623 | 0.76 | BAZ2B (0.54) | PTGDR2AKR1B10AKR1B1BAZ2BSMN1; SMN2 | |
| SCHEMBL1999770 | 0.74 | ELANE (0.50) | PTGDR2AKR1B1AKR1C3AKR1C2PTGS1 | |
| SCHEMBL11679442 | 0.72 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS1PTGS2KDM4E | |
| SCHEMBL11759394 | 0.72 | BAZ2B (0.46) | PTGDR2AKR1B10AKR1B1BAZ2BHPGD | |
| SCHEMBL11679719 | 0.71 | AKR1C3 (0.71) | PTGDR2AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL5316982 | 0.70 | LMNA (0.65) | BAZ2BHPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3083783 | 0.69 | PTGDR2 (1.00) | PTGDR2BAZ2BPTGER2PTGDRCYP2C9 | |
| SCHEMBL13102721 | 0.68 | KDM4E (0.42) | PTGS1PTGS2HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824821-A2 | CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION | PTC Therapeutics, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006058088-A2 | CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION | PTC THERAPEUTICS, INC. (US) | 2006-06-01 | — | — | WO | disclosed |