Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 4/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.46 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.46 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763322 | 0.89 | ELANE (0.54) | PDK4ELANEGRM1GRM5CNR1 | |
| SCHEMBL20112166 | 0.86 | PDK4 (0.58) | PDK4GRM1GRM5CNR1HTR6 | |
| SCHEMBL2080489 | 0.86 | PDK4 (0.52) | PDK4ELANEGRM1GRM5CNR1 | |
| SCHEMBL25936245 | 0.84 | PDK4 (0.56) | PDK4GRM1GRM5CNR1HTR6 | |
| SCHEMBL6359772 | 0.84 | NAMPT (0.42) | ELANEKDM1AJAK1NAMPT | |
| SCHEMBL2357533 | 0.84 | NAMPT (0.57) | PDK4ELANEGRM1GRM5HTR6 | |
| SCHEMBL16434777 | 0.83 | GRM1 (0.56) | PDK4GRM1GRM5CNR1HTR6 | |
| SCHEMBL1811363 | 0.83 | PDK4 (0.55) | PDK4GRM1GRM5CNR1HTR6 | |
| SCHEMBL29744827 | 0.83 | PDK4 (0.55) | PDK4GRM1GRM5CNR1HTR6 | |
| SCHEMBL19701841 | 0.83 | CNR1 (0.55) | PDK4GRM1GRM5CNR1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005117882-A9 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | INCYTE CORP (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2005117882-A9 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | INCYTE CORP (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2005117882-A2 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | INCYTE CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
| WO-2005117882-A2 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | INCYTE CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20050250789-A1 | Hydroxamic acid derivatives as metalloprotease inhibitors | INCYTE CORPORATION | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250789-A1 | Hydroxamic acid derivatives as metalloprotease inhibitors | MMP9, MMP17, MMP25 | PDK4 3673/4885ELANE 134/4885GRM1 2840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.