MMP25 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL14823011	0.59	7/20
Iodide (SCHEMBL3680757)	0.57	7/20
Iodide (SCHEMBL3680762)	0.57	7/20
SCHEMBL3676623	0.55	7/20
SCHEMBL13410001	0.55	7/20
Trifluoroacetic Acid (SCHEMBL3679726)	0.50	7/20
Trifluoroacetic Acid (SCHEMBL3679731)	0.50	7/20
SCHEMBL27854134	0.49	7/20
SCHEMBL3679728	0.49	7/20
SCHEMBL14822934	0.48	4/20
Iodide (SCHEMBL3683383)	0.46	4/20
Iodide (SCHEMBL3683387)	0.46	4/20
SCHEMBL17613267	0.45	4/20
SCHEMBL14823005	0.45	4/20
SCHEMBL15849297	0.44	4/20
SCHEMBL15849302	0.44	4/20
SCHEMBL3683027	0.36	4/20
SCHEMBL22279796	0.52	3/20
SCHEMBL15849271	0.49	3/20
SCHEMBL15849272	0.49	3/20

Clinical trials — most relevant to MMP25 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Doxycycline In Lymphangioleiomyomatosis (LAM)	PHASE4	COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma	PHASE2	UNKNOWN
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer	PHASE1	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Periodontal Health in Post COVID-19 Patients	nan	UNKNOWN
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Prognostic Indices of Atheromatosis Severity and Coronary Artery Bypass Surgery Outcomes for Patients With Coronary Artery Disease	nan	ACTIVE_NOT_RECRUITING
Matrix Metalloproteinase (MMP) in Heart Failure	nan	COMPLETED
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity	nan	WITHDRAWN
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation	nan	COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
Influence of Short AV Delay Permanent Pacing on Matrix Metalloproteinase Levels	nan	COMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Interest of Dosage of Anti-PB230, Anti-PB180 and Cytokines for Monitoring of Patients Suffering From Bullous Pemphigoid	nan	COMPLETED
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma	nan	COMPLETED
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus	nan	COMPLETED
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MMP25 binder may also engage these)

Protein	Name	Similarity
Q3U435	—	0.999	Q3U435 →
Q499S5	—	0.997	Q499S5 →
Q9R0S3	—	0.996	Q9R0S3 →
MMP11	Stromelysin-3	0.995	landscape →
Q9H239	—	0.993	Q9H239 →
Q02853	—	0.991	Q02853 →
MMP17	Matrix metalloproteinase-17	0.989	landscape →
Q99542	—	0.988	Q99542 →
Q9JHI0	—	0.986	Q9JHI0 →
Q8BYG9	—	0.985	Q8BYG9 →
MMP15	Matrix metalloproteinase-15	0.984	landscape →
Q96SM3	—	0.983	Q96SM3 →
Q5R543	—	0.983	Q5R543 →
INSRR	Insulin receptor-related protein	0.983	landscape →
Q6MG64	—	0.982	Q6MG64 →
Q91V24	—	0.982	Q91V24 →
O54732	—	0.982	O54732 →
Q9Y334	—	0.981	Q9Y334 →
Q91X72	—	0.981	Q91X72 →
F12	Coagulation factor XII	0.981	landscape →
O08644	—	0.981	O08644 →
EPHB4	Ephrin type-B receptor 4	0.980	landscape →
Q95220	—	0.980	Q95220 →
Q9R0S2	—	0.980	Q9R0S2 →
P53690	—	0.980	P53690 →
O95754	—	0.980	O95754 →
Q9XT90	—	0.980	Q9XT90 →
P52785	—	0.980	P52785 →
Q99PW6	—	0.980	Q99PW6 →
Q9UK23	—	0.979	Q9UK23 →