Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488961 | 0.90 | OPRL1 (0.48) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL16618534 | 0.87 | OPRL1 (0.49) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL13480017 | 0.84 | OPRM1 (0.56) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL30954700 | 0.83 | OPRL1 (0.48) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL17983435 | 0.83 | OPRL1 (0.44) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL25357037 | 0.83 | POLB (0.52) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL4978067 | 0.83 | OPRM1 (0.57) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL3840904 | 0.83 | MAPT (0.44) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL17983439 | 0.81 | OPRM1 (0.41) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL25314820 | 0.81 | CASP3 (0.43) | OPRM1OPRL1OPRK1OPRD1IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817310-A1 | (SPIROCYCLYLAMIDO) AMINOTHIOPHENE COMPOUNDS AS C-KIT PROTO-ONCOGENE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006034015-A1 | (SPIROCYCLYLAMIDO) AMINOTHIOPHENE COMPOUNDS AS C-KIT PROTO- ONCOGENE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |