Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322230 | 0.79 | GPR119 (0.49) | GPR119SIGMAR1 | |
| SCHEMBL5319956 | 0.78 | HTR2A (0.51) | GPR119KDM4ESIGMAR1HTR2ADRD2 | |
| SCHEMBL5319145 | 0.76 | GPR119 (0.42) | GPR119SIGMAR1HTR2ADRD2HTR2C | |
| SCHEMBL5320769 | 0.76 | GPR119 (0.54) | GPR119SIGMAR1HTR2ADRD2HTR2C | |
| SCHEMBL20270792 | 0.71 | GPR119 (0.38) | GPR119SIGMAR1HTR2ADRD2HTR2C | |
| SCHEMBL5320781 | 0.71 | HTR2A (0.45) | GPR119SIGMAR1HTR2ADRD2HTR2C | |
| SCHEMBL20271239 | 0.71 | GPR119 (0.41) | GPR119SIGMAR1HTR2ADRD2HTR2C | |
| SCHEMBL5320036 | 0.70 | SIGMAR1 (0.46) | SIGMAR1HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL25814892 | 0.68 | SIGMAR1 (0.44) | GPR119SIGMAR1HTR2ADRD2HTR2C | |
| SCHEMBL20270560 | 0.67 | GPR119 (0.47) | GPR119SIGMAR1HTR2ADRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | claimed |