Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.51 |
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | HTR2C | P28335 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435759 | 0.88 | HTR2A (0.48) | HTR2ADRD2HTR2CKCNH2EPHX2 | |
| SCHEMBL5319145 | 0.83 | GPR119 (0.42) | HTR2ADRD2HTR2CKCNH2GPR119 | |
| SCHEMBL5322230 | 0.80 | GPR119 (0.49) | GPR119SIGMAR1 | |
| SCHEMBL5320781 | 0.80 | HTR2A (0.45) | HTR2ADRD2HTR2CKCNH2GPR119 | |
| SCHEMBL5320036 | 0.79 | SIGMAR1 (0.46) | HTR2ADRD2HTR2CKCNH2SIGMAR1 | |
| SCHEMBL5320769 | 0.78 | GPR119 (0.54) | HTR2ADRD2HTR2CEPHX2GPR119 | |
| SCHEMBL20271239 | 0.78 | GPR119 (0.41) | HTR2ADRD2HTR2CKCNH2GPR119 | |
| SCHEMBL5320536 | 0.78 | METAP2 (0.39) | HTR2ADRD2HTR2CKCNH2GPR119 | |
| SCHEMBL25814892 | 0.77 | SIGMAR1 (0.44) | HTR2ADRD2HTR2CKCNH2EPHX2 | |
| SCHEMBL5321529 | 0.75 | HTR2A (0.43) | HTR2ADRD2HTR2CKCNH2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | claimed |
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | disclosed |