Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316471 | 0.81 | CD274 (0.56) | CD274EPHX2CHRM4NAMPTALDH1A1 | |
| SCHEMBL5318392 | 0.79 | CD274 (0.58) | CD274EPHX2CHRM4NAMPTDPP4 | |
| SCHEMBL5314456 | 0.79 | EPHX2 (0.52) | CD274EPHX2CHRM4 | |
| SCHEMBL5316201 | 0.78 | CD274 (0.51) | CD274EPHX2CHRM4NAMPTKCNH2 | |
| SCHEMBL5316139 | 0.78 | CD274 (0.51) | CD274CHRM4NAMPT | |
| SCHEMBL5315537 | 0.78 | CD274 (0.48) | CD274CHRM4NAMPT | |
| SCHEMBL5314554 | 0.78 | KCNH2 (0.53) | CD274EPHX2NAMPTKCNH2 | |
| SCHEMBL5315942 | 0.77 | CD274 (0.56) | CD274EPHX2CHRM4NAMPTDPP4 | |
| SCHEMBL5317499 | 0.77 | CD274 (0.56) | CD274EPHX2CHRM4NAMPTHPGD | |
| SCHEMBL5318987 | 0.77 | CD274 (0.56) | CD274EPHX2CHRM4NAMPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |