Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL10340639 | 1.00 | ALDH1A1 (0.40) | — | |
| Pimagedine SCHEMBL9716859 | 1.00 | — | — | |
| Pimagedine SCHEMBL15307 | 0.95 | — | — | |
| Pimagedine SCHEMBL7763659 | 0.95 | ALDH1A1 (0.43) | — | |
| Pimagedine SCHEMBL27366958 | 0.95 | ALDH1A1 (0.43) | — | |
| Pimagedine SCHEMBL23779762 | 0.91 | — | — | |
| Pimagedine SCHEMBL4879214 | 0.91 | — | — | |
| Pimagedine SCHEMBL3818920 | 0.91 | — | — | |
| Pimagedine SCHEMBL8446446 | 0.91 | — | — | |
| Pimagedine SCHEMBL9734994 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118930459-A | Lead compound of targeted human lipocalin 2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2024-11-12 | — | — | CN | claimed |
| CN-116102468-B | Lead compound of targeted human lipocalin 2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2024-07-09 | — | — | CN | claimed |
| CN-116102468-A | Lead compound of targeted human lipocalin2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2023-05-12 | — | — | CN | claimed |
| EP-0788488-A4 | IMPROVED PROCESS FOR THE PREPARATION OF 5-AMINOTETRAZOLE | OLIN CORP (US) | 1998-01-28 | — | — | EP | claimed |
| EP-0788488-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-AMINOTETRAZOLE | OLIN CORPORATION (US) | 1997-08-13 | — | — | EP | claimed |
| US-5559243-A | Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole | NIPPON CARBIDE KOGYO KABUSHIKI KAISHA (JP) | 1996-09-24 | — | — | US | claimed |
| WO-1996013490-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-AMINOTETRAZOLE | OLIN CORPORATION (US) | 1996-05-09 | — | — | WO | claimed |
| US-5424449-A | Reacting aminoguanidine salt of mineral acid with a diazotization agent to form guanylazide salt; cyclization | OLIN CORPORATION (US) | 1995-06-13 | — | — | US | claimed |
| WO-2025022310-A1 | A METHOD FOR PREPARING 1-ALKYL-1H-1,2,4-TRAIZOL-3-AMINE COMPOUNDS | PI INDUSTRIES LTD. (IN) | 2025-01-30 | — | — | WO | disclosed |
| CN-118930459-A | Lead compound of targeted human lipocalin 2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2024-11-12 | — | — | CN | disclosed |
| CN-116102468-B | Lead compound of targeted human lipocalin 2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2024-07-09 | — | — | CN | disclosed |
| CN-116102468-A | Lead compound of targeted human lipocalin2 or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国科学技术大学 | 2023-05-12 | — | — | CN | disclosed |
| EP-3508516-B1 | VULCANIZED RUBBER COMPOSITION AND PRODUCTION PROCESS THEREFOR | MITSUBISHI GAS CHEMICAL CO (JP) | 2020-09-23 | — | — | EP | disclosed |
| US-10465016-B2 | Modified rubber for tire, rubber composition for tire using the same, and tire | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2019-11-05 | — | — | US | disclosed |
| US-20180355074-A1 | VULCANIZED RUBBER COMPOSITION AND PRODUCTION METHOD THEREOF | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2018-12-13 | — | — | US | disclosed |
| US-20170121429-A1 | MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE USING THE SAME, AND TIRE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2017-05-04 | — | — | US | disclosed |
| EP-3156426-A1 | MODIFIED RUBBER FOR TYRE, RUBBER COMPOSITION FOR TYRE USING SAID MODIFIED RUBBER AND TYRE | Mitsubishi Gas Chemical Company, Inc. (JP) | 2017-04-19 | — | — | EP | disclosed |
| WO-2007104383-A1 | TEGASEROD HEMIMALEATE AND A PROCESS FOR ITS PREPARATION | NOVARTIS AG (CH) | 2007-09-20 | — | — | WO | disclosed |
| US-5714617-A | Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole | NIPPON CARBIDE KOGYO KABUSHIKI KAISHA (JP) | 1998-02-03 | — | — | US | disclosed |
| US-5559243-A | Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole | NIPPON CARBIDE KOGYO KABUSHIKI KAISHA (JP) | 1996-09-24 | — | — | US | disclosed |