Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL10340639 | 1.00 | ALDH1A1 (0.40) | — | |
| Pimagedine SCHEMBL5320871 | 1.00 | — | — | |
| Pimagedine SCHEMBL15307 | 0.95 | — | — | |
| Pimagedine SCHEMBL7763659 | 0.95 | ALDH1A1 (0.43) | — | |
| Pimagedine SCHEMBL27366958 | 0.95 | ALDH1A1 (0.43) | — | |
| Pimagedine SCHEMBL23779762 | 0.91 | — | — | |
| Pimagedine SCHEMBL4879214 | 0.91 | — | — | |
| Pimagedine SCHEMBL3818920 | 0.91 | — | — | |
| Pimagedine SCHEMBL8446446 | 0.91 | — | — | |
| Pimagedine SCHEMBL9734994 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128122-A | Nitrogen compound | THE ROCKEFELLER UNIVERSITY (US) | 1992-07-07 | — | — | US | disclosed |