Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GYS1 | P13807 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322267 | 0.91 | PARP1 (0.50) | PARP1TRPA1CYP2B6CYP1A1CYP1A2 | |
| SCHEMBL30066970 | 0.91 | PARP1 (0.50) | PARP1TRPA1CYP2B6CYP1A1CYP1A2 | |
| SCHEMBL30629173 | 0.81 | CYP2B6 (0.42) | PARP1TRPA1CYP2B6CYP1A1CYP1A2 | |
| SCHEMBL1748858 | 0.81 | CYP2B6 (0.42) | PARP1TRPA1CYP2B6CYP1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6245847 | 0.79 | CYP2B6 (0.41) | PARP1TRPA1CYP2B6CYP1A1CYP1A2 | |
| SCHEMBL27845712 | 0.79 | CYP2B6 (0.48) | PARP1TRPA1CYP2B6CYP1A1CYP1A2 | |
| SCHEMBL31058480 | 0.78 | CYP2B6 (0.39) | PARP1CYP2B6CYP1A1CYP1A2KDM4E | |
| SCHEMBL5321524 | 0.77 | PARP1 (0.38) | PARP1TRPA1KDM4EALDH1A1CYP11B1 | |
| SCHEMBL10668243 | 0.74 | AKR1B1 (0.41) | TRPA1CYP2B6CYP1A1CYP1A2KDM4E | |
| SCHEMBL30629212 | 0.72 | CYP2B6 (0.39) | PARP1CYP2B6CYP1A1CYP1A2GYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096352-A1 | 5-AMINO-6-BROMO-N-{ [1- (TETRAHYDR0-2H-PYRAN-4-YLMETHYL) -4-PIPERIDINYL] METHYL}-3, 4 -DIHYDRO-2H-CHROMENE-8-CARBOXAMIDE AS 5-HT4 RECEPTOR AGONIST | GLAXO GROUP LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |