Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066970 | 1.00 | PARP1 (0.50) | PARP1TRPA1CYP2B6ALDH1A1KDM4E | |
| Succinic Acid SCHEMBL5320883 | 0.91 | PARP1 (0.43) | PARP1TRPA1CYP2B6ALDH1A1KDM4E | |
| SCHEMBL27845712 | 0.86 | CYP2B6 (0.48) | PARP1TRPA1CYP2B6ALDH1A1KDM4E | |
| SCHEMBL30629173 | 0.85 | CYP2B6 (0.42) | PARP1TRPA1CYP2B6ALDH1A1KDM4E | |
| SCHEMBL1748858 | 0.85 | CYP2B6 (0.42) | PARP1TRPA1CYP2B6ALDH1A1KDM4E | |
| SCHEMBL5321524 | 0.84 | PARP1 (0.38) | PARP1TRPA1ALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL6245847 | 0.83 | CYP2B6 (0.41) | PARP1TRPA1CYP2B6ALDH1A1KDM4E | |
| SCHEMBL31058480 | 0.83 | CYP2B6 (0.39) | PARP1CYP2B6ALDH1A1KDM4EMAPT | |
| SCHEMBL27383030 | 0.80 | TRPA1 (0.46) | TRPA1CYP2B6ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30629212 | 0.76 | CYP2B6 (0.39) | PARP1CYP2B6CYP1A1CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233087-A1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | Axovant Sciences GmbH (DE) | 2017-10-25 | — | — | EP | claimed |
| WO-2016100184-A1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2016-06-23 | — | — | WO | claimed |
| CN-117015530-A | Urolithin derivatives and methods of use thereof | 范徳利亚股份公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3233087-A1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | Axovant Sciences GmbH (DE) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100184-A1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2007096352-A1 | 5-AMINO-6-BROMO-N-{ [1- (TETRAHYDR0-2H-PYRAN-4-YLMETHYL) -4-PIPERIDINYL] METHYL}-3, 4 -DIHYDRO-2H-CHROMENE-8-CARBOXAMIDE AS 5-HT4 RECEPTOR AGONIST | GLAXO GROUP LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |
| CN-1300277-A | Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-20 | — | — | CN | disclosed |