Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CCKBR | P32239 | 10/20 | 0.47 |
| ▸ | CCKAR | P32238 | 4/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320618 | 0.92 | PTH1R (0.55) | PTH1RALDH1A1CCKBRCCKARCASP1 | |
| SCHEMBL5320334 | 0.83 | PTH1R (0.69) | PTH1RALDH1A1CCKBR | |
| SCHEMBL5323577 | 0.80 | PTH1R (0.47) | PTH1RALDH1A1CCKBRCCKARCASP1 | |
| SCHEMBL5320380 | 0.77 | PTH1R (0.57) | PTH1RHPGDHTTCCKBR | |
| SCHEMBL5324664 | 0.76 | PTH1R (0.58) | PTH1RCCKBRCASP1CASP3CASP4 | |
| SCHEMBL5321708 | 0.76 | PTH1R (0.56) | PTH1RALDH1A1CASP1CASP3CASP4 | |
| SCHEMBL5322971 | 0.74 | PTH1R (0.54) | PTH1RCCKBRCASP1CASP3CASP4 | |
| SCHEMBL5327910 | 0.74 | PTH1R (0.56) | PTH1RCCKBR | |
| SCHEMBL5280948 | 0.73 | PTH1R (0.76) | PTH1RCCKBRCCKAR | |
| SCHEMBL5325678 | 0.73 | PTH1R (0.57) | PTH1RCASP1CASP3CASP4CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |