Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321454 | 0.87 | MAPT (0.57) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL11710551 | 0.86 | KDM4E (0.57) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29900467 | 0.86 | KDM4E (0.57) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5320690 | 0.86 | MAPT (0.60) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2204262 | 0.84 | TDP1 (0.54) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1492578 | 0.82 | KDM4E (0.55) | TDP1MAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5326091 | 0.80 | MAPT (0.57) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5658063 | 0.78 | MAPT (0.61) | TDP1MAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL18786142 | 0.76 | ALDH1A1 (0.54) | TDP1MAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL128402 | 0.76 | LOXL2 (0.61) | MAPTALDH1A1SMN1; SMN2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091140-A1 | SUBSTITUTED PHENYLSULFAMOYL COMPOUNDS AS PPAR AGONISTS | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |