Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492578 | 0.83 | KDM4E (0.55) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL1492538 | 0.82 | ALDH1A1 (0.59) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13539390 | 0.79 | ALDH1A1 (0.56) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL3506729 | 0.78 | KDM4E (0.77) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL25358 | 0.78 | KDM4E (0.62) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL29402979 | 0.78 | KDM4E (0.62) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| Hydrogen Sulfide SCHEMBL21332206 | 0.77 | KDM4E (0.60) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL3249905 | 0.77 | ALDH1A1 (0.55) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4485136 | 0.77 | KDM4E (0.53) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL5321709 | 0.76 | TDP1 (0.57) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | GENENTECH INC (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | STS, TST, SCLY | ALDH1A1 143/4885RAB9A 3224/4885KDM4E 3411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.