Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327587 | 0.86 | ALDH1A1 (0.74) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6297588 | 0.86 | ALDH1A1 (0.81) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5319979 | 0.86 | ALDH1A1 (0.65) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5325411 | 0.85 | RAB9A (0.65) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5323948 | 0.84 | ALDH1A1 (0.63) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5330701 | 0.84 | ATM (0.71) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5322523 | 0.83 | ALDH1A1 (0.65) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5324271 | 0.83 | ALDH1A1 (0.61) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5322502 | 0.83 | ALDH1A1 (0.68) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12880514 | 0.82 | EPHX2 (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | claimed |
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |