Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 2/20 | 0.60 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PNLIP | P16233 | 1/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5282610 | 0.81 | GRK2 (0.58) | GRK2PTGER2HIF1AFFAR1PPARG | |
| SCHEMBL27144496 | 0.81 | HIF1A (0.53) | GRK2HIF1APPARGKCNQ3KCNQ2 | |
| SCHEMBL5287709 | 0.80 | ALDH1A1 (0.59) | GRK2FFAR1 | |
| SCHEMBL5413973 | 0.78 | FFAR1 (0.51) | GRK2FFAR1 | |
| SCHEMBL1430415 | 0.78 | MEN1 (0.58) | GRK2PTGER2FFAR1 | |
| SCHEMBL27112845 | 0.76 | PPARG (0.59) | PPARG | |
| SCHEMBL5537424 | 0.76 | GRK2 (1.00) | GRK2 | |
| Hydrochloric Acid SCHEMBL20546808 | 0.75 | KMT2A (0.53) | GRK2HIF1AFFAR1BRD4PPARG | |
| Hydrochloric Acid SCHEMBL20546809 | 0.75 | KMT2A (0.53) | GRK2HIF1AFFAR1BRD4PPARG | |
| SCHEMBL9795747 | 0.75 | NR4A2 (0.63) | FFAR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |