Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.57 |
| ▸ | GRK2 | P25098 | 3/20 | 0.55 |
| ▸ | GRK3 | P35626 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | GRK5 | P34947 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284916 | 0.90 | GRK2 (0.57) | ALDH1A1MAPK1MITFPOLBHTT | |
| SCHEMBL5301594 | 0.90 | GRK2 (0.57) | ALDH1A1MAPK1MITFPOLBHTT | |
| SCHEMBL8021547 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPK1MITFPOLBHTT | |
| SCHEMBL5282610 | 0.85 | GRK2 (0.58) | ALDH1A1MAPK1MITFPOLBHTT | |
| SCHEMBL5413973 | 0.85 | FFAR1 (0.51) | ALDH1A1MAPK1MITFPOLBHTT | |
| SCHEMBL5954356 | 0.84 | FFAR1 (0.59) | ALDH1A1HTTFFAR1HDAC3HDAC4 | |
| SCHEMBL10439096 | 0.84 | MAPK1 (0.56) | ALDH1A1MAPK1MITFPOLBHTT | |
| SCHEMBL5285556 | 0.83 | MTNR1A (0.61) | MITFHTTGRK2GRK3GRK5 | |
| SCHEMBL340537 | 0.82 | AKR1C3 (0.55) | ALDH1A1LMNAMAPTAKR1C3 | |
| SCHEMBL5287947 | 0.81 | FFAR1 (0.62) | ALDH1A1FFAR1GRK2GRK3GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135499-A1 | Hydrazide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | US | disclosed |
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135499-A1 | Hydrazide compounds | GRK4, GRK2, GRK1 | ALDH1A1 2861/4885MAPK1 852/4885MITF 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.