Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 6/20 | 0.58 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GRK3 | P35626 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287709 | 0.85 | ALDH1A1 (0.59) | GRK2FFAR1MITFALDH1A1POLB | |
| SCHEMBL5301594 | 0.82 | GRK2 (0.57) | GRK2FFAR1MITFALDH1A1POLB | |
| SCHEMBL5284916 | 0.82 | GRK2 (0.57) | GRK2FFAR1MITFALDH1A1POLB | |
| SCHEMBL5322943 | 0.81 | GRK2 (0.60) | GRK2PTGER2PPARAFFAR1HIF1A | |
| SCHEMBL188668 | 0.78 | RAB9A (0.50) | FFAR1ALDH1A1POLBHTTHDAC4 | |
| SCHEMBL14384830 | 0.77 | MTNR1A (0.57) | ALDH1A1MAPK1HTT | |
| SCHEMBL5285556 | 0.76 | MTNR1A (0.61) | GRK2MITFHTTGRK3GRK5 | |
| SCHEMBL3611216 | 0.75 | ALDH1A1 (0.50) | GRK2FFAR1ALDH1A1POLBHTT | |
| SCHEMBL5413973 | 0.75 | FFAR1 (0.51) | GRK2FFAR1MITFALDH1A1POLB | |
| SCHEMBL340537 | 0.75 | AKR1C3 (0.55) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |