Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ILK | Q13418 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29117998 | 0.81 | RAB9A (0.46) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL713163 | 0.75 | RAB9A (0.50) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL827403 | 0.74 | RAB9A (0.67) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5323730 | 0.73 | RAB9A (0.47) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28115653 | 0.73 | ILK (0.60) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| Hydrogen Sulfide SCHEMBL28205214 | 0.72 | RAB9A (0.64) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| Hydrogen Sulfide SCHEMBL16859912 | 0.72 | RAB9A (0.64) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| Methane SCHEMBL28056221 | 0.72 | RAB9A (0.64) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15987517 | 0.72 | RAB9A (0.47) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6642970 | 0.72 | RAB9A (0.51) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |