Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18736058 | 0.85 | MTNR1A (0.72) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL6376395 | 0.84 | MTNR1A (0.71) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL14027269 | 0.83 | ALDH1A1 (0.72) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL14027267 | 0.83 | ALDH1A1 (0.72) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL9416664 | 0.82 | NPC1 (0.69) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL5211526 | 0.82 | MTNR1A (0.82) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL6376361 | 0.81 | ALDH1A1 (0.73) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL6377560 | 0.81 | ALDH1A1 (0.73) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL17212227 | 0.80 | MTNR1A (0.66) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL6095074 | 0.80 | POLB (0.60) | KMT2AMEN1ALDH1A1PKMCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007120083-A1 | THE USE OF CARBOXAMIDE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND DERMATOLOGICAL CONDITIONS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |