Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320857 | 0.88 | PTH1R (0.36) | CNR2 | |
| SCHEMBL5320053 | 0.88 | CHRM1 (0.38) | CNR2 | |
| SCHEMBL5331877 | 0.86 | CES2 (0.32) | LMNACNR2 | |
| SCHEMBL5321521 | 0.86 | PTH1R (0.38) | LMNAMAPK1SMN1; SMN2NPSR1BRD4 | |
| SCHEMBL5327710 | 0.85 | ALDH1A1 (0.33) | LMNAHPGDSMN1; SMN2NPSR1CNR2 | |
| SCHEMBL5323094 | 0.81 | PDE4B (0.39) | HPGDMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL5349124 | 0.80 | CNR2 (0.31) | CNR2 | |
| SCHEMBL5330541 | 0.78 | PTH1R (0.37) | CNR2 | |
| SCHEMBL5319651 | 0.77 | PTH1R (0.37) | — | |
| SCHEMBL5285662 | 0.77 | CES2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |