Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188098 | 0.94 | HPGD (0.65) | CYP2C9HPGDHTTMEN1KMT2A | |
| SCHEMBL22015905 | 0.94 | HPGD (0.65) | CYP2C9HPGDHTTMEN1KMT2A | |
| SCHEMBL20187714 | 0.89 | HPGD (0.59) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL3067260 | 0.88 | ALDH1A1 (0.58) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL28242074 | 0.87 | HPGD (0.61) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL3898465 | 0.87 | HPGD (0.61) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8205972 | 0.87 | ALDH1A1 (0.58) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8703730 | 0.86 | MAPT (0.73) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL2943824 | 0.86 | KMT2A (0.61) | HPGDHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL20639893 | 0.86 | HPGD (0.56) | HPGDHTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11485745-B2 | Amido spirocyclic amide and sulfonamide derivatives | VALO HEALTH, INC. (US) | 2022-11-01 | — | — | US | disclosed |
| US-20210171545-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | VALO HEALTH, INC. | 2021-06-10 | — | — | US | disclosed |
| WO-2021076886-A1 | 3-PHENYLSULPHONYL-QUINOLINE DERIVATIVES AS AGENTS FOR TREATING PATHOGENIC BLOOD VESSELS DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-04-22 | — | — | WO | disclosed |
| US-10882861-B2 | Purine nucleotide derivatives | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-01-05 | — | — | US | disclosed |
| US-10882861-B2 | Purine nucleotide derivatives | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-01-05 | — | — | US | disclosed |
| CN-104520290-B | Amido spirocyclic amide and sulfonamide derivatives | 基因科技股份有限公司 | 2020-10-09 | — | — | CN | disclosed |
| US-10730889-B2 | Amido spirocyclic amide and sulfonamide derivatives | FORMA TM, LLC (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190300532-A1 | PURINE NUCLEOTIDE DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-10-03 | — | — | US | disclosed |
| US-20190300532-A1 | PURINE NUCLEOTIDE DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-10-03 | — | — | US | disclosed |
| US-20180339998-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | Valo Health, LLC | 2018-11-29 | — | — | US | disclosed |
| US-20170216262-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | VALO EARLY DISCOVERY, INC. | 2017-08-03 | — | — | US | disclosed |
| WO-2017041665-A1 | 3-(N,N-DISUBSTITUTED AMINO GROUP) PROPANAMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN MEDICINE | 沈阳药科大学 | 2017-03-16 | — | — | WO | disclosed |
| EP-2820008-B1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | GENENTECH INC (US) | 2016-12-14 | — | — | EP | disclosed |
| CN-106146493-A | Pyrazolo [3,4-b] pyridines and the preparation method of indazole compounds and purposes | 中国科学院上海药物研究所 | 2016-11-23 | — | — | CN | disclosed |
| US-20160002266-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | GENENTECH, INC. (US) | 2016-01-07 | — | — | US | disclosed |
| CN-104520290-A | Amido spirocyclic amide and sulfonamide derivatives | GENENTECH INC | 2015-04-15 | — | — | CN | disclosed |
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |
| WO-2007099166-A1 | PYRAZOLO-PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-09-07 | — | — | WO | disclosed |
| EP-0228192-A2 | Renin-inhibitory oligopeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0186977-A2 | Renin-inhibitory dipeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-07-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002266-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | STS, AADAC, SULT2A1 | CYP2C9 594/4885HPGD 1191/4885HTT 965/4885 |
| US-20170216262-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | STS, AADAC, SULT2A1 | CYP2C9 594/4885HPGD 1191/4885HTT 965/4885 |
| US-20210171545-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | STS, AADAC, SULT2A1 | CYP2C9 594/4885HPGD 1191/4885HTT 965/4885 |
| US-11485745-B2 | Amido spirocyclic amide and sulfonamide derivatives | STS, AADAC, SULT2A1 | CYP2C9 594/4885HPGD 1191/4885HTT 965/4885 |
| US-20180339998-A1 | AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES | STS, AADAC, SULT2A1 | CYP2C9 594/4885HPGD 1191/4885HTT 965/4885 |
| US-10882861-B2 | Purine nucleotide derivatives | PNP, NT5C2, NUDT1 | CYP2C9 2635/4885HPGD 594/4885HTT 4338/4885 |
| US-20190300532-A1 | PURINE NUCLEOTIDE DERIVATIVES | PNP, NT5C2, NUDT1 | CYP2C9 2635/4885HPGD 594/4885HTT 4338/4885 |
| US-10730889-B2 | Amido spirocyclic amide and sulfonamide derivatives | STS, AADAC, SULT2A1 | CYP2C9 594/4885HPGD 1191/4885HTT 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.