Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.56 |
| ▸ | EDNRB | P24530 | 6/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5529599 | 0.83 | EDNRA (0.63) | EDNRAEDNRBBRD4 | |
| SCHEMBL30171185 | 0.83 | EDNRA (0.63) | EDNRAEDNRBBRD4 | |
| SCHEMBL30296336 | 0.78 | EDNRA (0.56) | EDNRAEDNRBBRD4FBP1 | |
| SCHEMBL5321684 | 0.78 | EDNRA (0.56) | EDNRAEDNRBBRD4FBP1 | |
| SCHEMBL30844573 | 0.78 | EDNRA (0.56) | EDNRAEDNRBBRD4RXFP1FBP1 | |
| SCHEMBL5330400 | 0.78 | EDNRA (0.56) | EDNRAEDNRBBRD4RXFP1FBP1 | |
| SCHEMBL29280990 | 0.72 | EDNRA (0.50) | EDNRAEDNRBBRD4 | |
| SCHEMBL6640611 | 0.72 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7858770 | 0.70 | EDNRA (0.76) | EDNRAEDNRBBRD4 | |
| SCHEMBL4772910 | 0.69 | EDNRA (0.59) | EDNRAEDNRBBRD4FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109456-A2 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2007-09-27 | — | — | WO | disclosed |