Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.49 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325203 | 0.82 | L3MBTL1 (0.49) | POLBALDH1A1GAAL3MBTL1ENPP2 | |
| SCHEMBL4080945 | 0.78 | TSHR (0.64) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL7107371 | 0.78 | POLB (0.82) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL7828620 | 0.77 | ALDH1A1 (0.70) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL7824236 | 0.74 | HDAC3 (0.71) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL5009594 | 0.74 | SRC (0.44) | POLBENPP2DGAT2MEN1KMT2A | |
| SCHEMBL24040103 | 0.74 | POLB (0.70) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL3139569 | 0.74 | POLB (0.70) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL7825018 | 0.74 | POLB (0.70) | POLBALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL29714924 | 0.72 | POLB (0.68) | POLBALDH1A1GAAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007138381-A2 | PHOSPHONATED OXAZOLIDINONES AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC. (CA) | 2007-12-06 | — | — | WO | disclosed |