SCHEMBL5326009

SCHEMBL5326009

CCCCCc1ccc2c(N)c(OC(N)=O)sc2n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.48
KDM4E B2RXH2 6/20 0.45
HSD17B10 Q99714 1/20 0.45
IKBKB O14920 2/20 0.41
RAB9A P51151 6/20 0.38
HPGD P15428 6/20 0.38
NPC1 O15118 5/20 0.38
SMN1; SMN2 Q16637 5/20 0.38
LIMK1 P53667 2/20 0.38
KCNH2 Q12809 1/20 0.36
ALDH1A1 P00352 3/20 0.35
NFKB1 P19838 2/20 0.35
NFKB2 Q00653 2/20 0.35
RELA Q04206 2/20 0.35
MAPT P10636 5/20 0.34
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
TLR9 Q9NR96 2/20 0.34
MCL1 Q07820 2/20 0.34
TLR8 Q9NR97 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5354891 0.81 ADORA2A (0.60) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL12562456 0.76 ADORA2A (0.62) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL429337 0.72 ADORA2A (0.71) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL26780528 0.70 ADORA2A (0.73) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL14955421 0.69 ADORA2A (0.75) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL26784104 0.68 ADORA2A (0.65) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL8801032 0.64 IKBKB (0.56) KDM4EIKBKBRAB9AHPGDNPC1
SCHEMBL19212248 0.64 ADORA2A (0.60) ADORA2AKDM4EHSD17B10IKBKBRAB9A
SCHEMBL13281601 0.63 KCNH2 (0.46) KDM4EIKBKBHPGDKCNH2ALDH1A1
SCHEMBL28477031 0.63 POLB (0.38) HPGDALDH1A1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006074919-A2 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS CURACYTE DISCOVERY GMBH (DE) 2006-07-20 WO claimed
WO-2006074919-A3 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS CURACYTE DISCOVERY GMBH (DE) 2007-02-01 WO disclosed
WO-2006074919-A2 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS CURACYTE DISCOVERY GMBH (DE) 2006-07-20 WO disclosed
WO-2006074919-A2 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS CURACYTE DISCOVERY GMBH (DE) 2006-07-20 WO disclosed