SCHEMBL5326147

SCHEMBL5326147

O=C(O)c1ccc(NS(=O)(=O)c2cccc(F)c2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
HDAC3 O15379 1/20 0.65
HDAC4 P56524 1/20 0.65
HDAC1 Q13547 1/20 0.65
HDAC7 Q8WUI4 1/20 0.65
HDAC2 Q92769 1/20 0.65
HDAC10 Q969S8 1/20 0.65
HDAC11 Q96DB2 1/20 0.65
HDAC8 Q9BY41 1/20 0.65
HDAC6 Q9UBN7 1/20 0.65
HDAC9 Q9UKV0 1/20 0.65
HDAC5 Q9UQL6 1/20 0.65
PGR P06401 2/20 0.64
KMT2A Q03164 5/20 0.62
MEN1 O00255 4/20 0.62
THRB P10828 1/20 0.62
GAA P10253 1/20 0.59
POLB P06746 2/20 0.59
MAPT P10636 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3554760 0.92 HDAC4 (0.61) LMNASMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL3556446 0.89 PGR (0.62) LMNASMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL3724198 0.87 THRB (0.79) LMNAKMT2AMEN1THRBPOLB
SCHEMBL2824710 0.86 THRB (0.81) LMNASMN1; SMN2KMT2AMEN1THRB
SCHEMBL16404742 0.86 LMNA (0.70) LMNASMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL400223 0.84 THRB (0.83) LMNAHDAC3HDAC4HDAC1HDAC7
SCHEMBL3556207 0.84 MEN1 (0.57) LMNASMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL3558145 0.84 THRB (0.57) LMNASMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL4815695 0.83 HDAC3 (0.70) LMNASMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL7177694 0.83 PGR (0.65) LMNASMN1; SMN2HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007144379-A1 BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS MEDIVIR AB (SE) 2007-12-21 WO disclosed
WO-2007144379-A1 BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS MEDIVIR AB (SE) 2007-12-21 WO disclosed