SCHEMBL532667

SCHEMBL532667

CC(C)(CCc1ccc(N)cc1)[Si](O[Si](c1ccccc1)(c1ccccc1)C(C)(C)CCc1ccc(N)cc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.46
MAOA P21397 3/20 0.46
GFER P55789 2/20 0.38
RAB9A P51151 5/20 0.38
NPC1 O15118 4/20 0.38
CYP19A1 P11511 5/20 0.37
HTR2A P28223 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.35
GAA P10253 2/20 0.35
SIGMAR1 Q99720 1/20 0.34
MAPT P10636 2/20 0.33
TP53 P04637 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
SLC6A2 P23975 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7795405 0.85 TAAR1 (0.35) HTR2ASIGMAR1SLC6A2TAAR1
SCHEMBL26028733 0.80 MAOB (0.47) MAOBMAOAGFERRAB9ANPC1
SCHEMBL5574146 0.78 CYP3A4 (0.41) HTTL3MBTL1
SCHEMBL7388153 0.77 CYP19A1 (0.40) MAOBCYP19A1L3MBTL1
SCHEMBL6617538 0.76 MAOB (0.49) MAOBMAOAGFERRAB9ANPC1
SCHEMBL7068809 0.76 GFER (0.45) MAOBMAOAGFERRAB9ANPC1
SCHEMBL8862091 0.73 TDP1 (0.49) SIGMAR1L3MBTL1
SCHEMBL8862044 0.73 TDP1 (0.49) SIGMAR1L3MBTL1
SCHEMBL8114078 0.72 SLC6A2 (0.35) RAB9ANPC1SMN1; SMN2HTTL3MBTL1
SCHEMBL222047 0.72 MAOB (0.43) MAOBMAOARAB9ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2415764-A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT Kowa Company, Ltd. (JP) 2012-02-08 EP disclosed
EP-2199283-A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA, COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT Kowa Company, Ltd. (JP) 2010-06-23 EP disclosed
EP-0708660-B1 COMPOUNDS USEFUL FOR PREPARING PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS CANCER RES CAMPAIGN TECH (GB) 2007-05-09 EP disclosed
EP-0804413-B1 NITROGEN MUSTARD PRODRUGS WITH NOVEL LIPOPHILIC PROTECTING GROUPS, AND PROCESSES FOR THEIR PRODUCTION CANCER RES CAMPAIGN TECH (GB) 2000-05-17 EP disclosed
US-6005002-A Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1999-12-21 US disclosed
US-5770731-A PROTECTING GROUPS, ANTIBODY DIRECTED ENZYME/PRODRUG THERAPY, ANTICARCINOGENIC AGENTS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1998-06-23 US disclosed
US-5728868-A Prodrugs of protein tyrosine kinase inhibitors CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1998-03-17 US disclosed
EP-0804413-A1 NITROGEN MUSTARD PRODRUGS WITH NOVEL LIPOPHILIC PROTECTING GROUPS, AND PROCESSES FOR THEIR PRODUCTION CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1997-11-05 EP disclosed
WO-1996022277-A1 NITROGEN MUSTARD PRODRUGS WITH NOVEL LIPOPHILIC PROTECTING GROUPS, AND PROCESSES FOR THEIR PRODUCTION CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1996-07-25 WO disclosed
EP-0708660-A1 PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1996-05-01 EP disclosed
WO-1995002420-A2 PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS CANCER RESEARCH CAMPAIGN TECHNOLOGY LTD. (GB) 1995-01-26 WO disclosed