Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532667 | 0.85 | MAOB (0.46) | TAAR1SIGMAR1SLC6A2HTR2A | |
| SCHEMBL8114078 | 0.84 | SLC6A2 (0.35) | TAAR1SLC6A2MMP13 | |
| SCHEMBL5574146 | 0.78 | CYP3A4 (0.41) | — | |
| SCHEMBL7388153 | 0.77 | CYP19A1 (0.40) | — | |
| SCHEMBL2466725 | 0.76 | PPARA (0.39) | TAAR1SIGMAR1HTR2ACXCR3HTR2C | |
| SCHEMBL2809804 | 0.76 | TAAR1 (0.40) | TAAR1HTR2A | |
| SCHEMBL7191335 | 0.74 | — | — | |
| SCHEMBL8862091 | 0.73 | TDP1 (0.49) | SIGMAR1 | |
| SCHEMBL8862044 | 0.73 | TDP1 (0.49) | SIGMAR1 | |
| SCHEMBL4587307 | 0.72 | IDO1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6211174-B1 | OSTEOPOROSIS; MILK PRODUCTION AND CARCASS QUALITY IN LIVESTOCK; SHORT STATURE; METABOLIC DISORDERS | MERCK & CO., INC. | 2001-04-03 | — | — | US | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0726901-A4 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 1997-01-22 | — | — | EP | disclosed |
| EP-0726901-A1 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5438136-A | Benzo-fused macrocycles promote release of growth hormone | MERCK & CO., INC. (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |
| WO-1995012598-A1 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-05-11 | — | — | WO | disclosed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |