Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.38 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8862044 | 1.00 | TDP1 (0.49) | TDP1L3MBTL1CALM1SIGMAR1MMP1 | |
| SCHEMBL8862099 | 0.79 | ALDH1A1 (0.45) | MMP1MMP2MMP3ALDH1A1 | |
| SCHEMBL8862123 | 0.79 | ALDH1A1 (0.45) | MMP1MMP2MMP3ALDH1A1 | |
| SCHEMBL7388153 | 0.77 | CYP19A1 (0.40) | L3MBTL1CALM1 | |
| SCHEMBL12040566 | 0.76 | TDP1 (0.75) | TDP1L3MBTL1CALM1SIGMAR1LTA4H | |
| SCHEMBL5966301 | 0.76 | TDP1 (0.75) | TDP1L3MBTL1CALM1SIGMAR1LTA4H | |
| SCHEMBL27665726 | 0.75 | TDP1 (0.52) | TDP1L3MBTL1CALM1SIGMAR1MMP1 | |
| SCHEMBL5632470 | 0.74 | LTA4H (0.69) | TDP1L3MBTL1CALM1SIGMAR1LTA4H | |
| SCHEMBL532667 | 0.73 | MAOB (0.46) | L3MBTL1SIGMAR1 | |
| SCHEMBL7795405 | 0.73 | TAAR1 (0.35) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656636-A | TREATING PSORIASIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5633258-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5631262-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |