SCHEMBL5326767

SCHEMBL5326767

O=C([CH]c1ccccc1)Nc1ccc(Cl)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 8/20 0.71
MMP2 P08253 8/20 0.71
MMP9 P14780 8/20 0.71
EGFR P00533 7/20 0.71
NPC1 O15118 5/20 0.58
SMN1; SMN2 Q16637 4/20 0.58
RAB9A P51151 4/20 0.58
ALDH1A1 P00352 3/20 0.58
MAPT P10636 3/20 0.58
KMT2A Q03164 3/20 0.58
MEN1 O00255 2/20 0.58
LMNA P02545 2/20 0.58
KDM4E B2RXH2 1/20 0.58
HTT P42858 2/20 0.54
GAA P10253 1/20 0.54
TGM2 P21980 1/20 0.52
MAOA P21397 2/20 0.51
MAOB P27338 2/20 0.51
DEGS1 O15121 1/20 0.50
CYP1A2 P05177 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL94335 0.87 TGM2 (0.67) MMP1MMP2MMP9EGFRSMN1; SMN2
N-(4-Chlorophenyl)Cinnamamide SCHEMBL8684664 0.83 MMP1 (1.00) MMP1MMP2MMP9EGFRNPC1
N-(4-Chlorophenyl)Cinnamamide SCHEMBL8684658 0.83 MMP1 (1.00) MMP1MMP2MMP9EGFRNPC1
SCHEMBL4985135 0.79 TAAR1 (0.59) MMP1MMP2MMP9EGFRNPC1
SCHEMBL1381911 0.77 TGM2 (0.66) MMP1MMP2MMP9EGFRNPC1
SCHEMBL15263182 0.76 MMP1 (0.88) MMP1MMP2MMP9EGFRNPC1
SCHEMBL7444420 0.75 MMP1 (0.61) MMP1MMP2MMP9EGFRNPC1
SCHEMBL15893618 0.75 NPC1 (0.63) MMP1MMP2MMP9EGFRNPC1
SCHEMBL11054644 0.75 CNR1 (0.74) NPC1SMN1; SMN2RAB9AALDH1A1MAPT
SCHEMBL4105004 0.75 CNR1 (0.74) NPC1SMN1; SMN2RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007119600-A1 CARBAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 WO disclosed